Cajun Chicken Alfredo Fettuccine

Featured in: Family Comfort Plates

This dish features juicy chicken breasts seasoned with Cajun spices and cooked until golden. The sauce blends Velveeta cheese, heavy cream, butter, garlic, and Parmesan for a velvety texture with a touch of heat from cayenne. Al dente fettuccine is tossed in the creamy sauce and topped with sliced chicken and fresh parsley, delivering a comforting meal with Southern flair.

Flexible and easy to prepare, it serves four and can be customized with additional vegetables or milder seasoning. Perfect for a weeknight dinner that combines bold flavors and smooth textures.

Updated on Sun, 23 Nov 2025 10:25:00 GMT
Tender Cajun Chicken Alfredo Fettuccine pasta swimming in a rich, creamy Velveeta sauce, ready to serve. Pin it
Tender Cajun Chicken Alfredo Fettuccine pasta swimming in a rich, creamy Velveeta sauce, ready to serve. | weeknightwhisk.com

A creamy, spicy pasta dish featuring tender Cajun-seasoned chicken, rich Velveeta cheese sauce, and perfectly cooked fettuccine—comfort food with a Southern twist.

This dish is a family favorite that I have made several times for gatherings and weeknight dinners alike

Ingredients

  • Chicken: 2 large boneless skinless chicken breasts 1 ½ tablespoons Cajun seasoning 1 tablespoon olive oil
  • Pasta: 12 oz (340 g) fettuccine pasta
  • Sauce: 2 tablespoons unsalted butter 2 cloves garlic minced 1 cup (240 ml) heavy cream 8 oz (225 g) Velveeta cheese cubed ½ cup (50 g) grated Parmesan cheese ½ teaspoon black pepper ¼ teaspoon cayenne pepper (optional for extra heat) Salt to taste
  • Garnish: 2 tablespoons fresh parsley chopped Extra grated Parmesan cheese (optional)

Instructions

Step 1:
Bring a large pot of salted water to a boil. Cook the fettuccine according to package instructions until al dente. Drain and set aside reserving ½ cup pasta water.
Step 2:
While the pasta cooks pat chicken breasts dry. Rub both sides with Cajun seasoning.
Step 3:
In a large skillet heat olive oil over medium-high heat. Add chicken and cook 5 6 minutes per side or until golden and cooked through (internal temperature 165°F/74°C). Remove chicken let rest 5 minutes then slice thinly.
Step 4:
In the same skillet reduce heat to medium. Add butter and garlic sauté 1 minute until fragrant.
Step 5:
Stir in heavy cream and bring to a gentle simmer. Add Velveeta cubes stirring often until melted and smooth.
Step 6:
Add Parmesan cheese black pepper and cayenne pepper (if using). Stir until fully combined and creamy. If sauce is too thick add reserved pasta water a little at a time.
Step 7:
Toss cooked fettuccine in the sauce until well coated.
Step 8:
Divide pasta among plates. Top with sliced Cajun chicken. Garnish with parsley and extra Parmesan if desired.
Pin it
| weeknightwhisk.com

This recipe never fails to bring everyone together around the dinner table sharing stories and enjoying each bite

Required Tools

Large pot Large skillet Knife and cutting board Tongs or pasta fork Measuring cups and spoons

Allergen Information

Contains milk/dairy (Velveeta Parmesan cream butter) Contains wheat (fettuccine) Contains chicken Those with allergies should check ingredient labels for hidden allergens

Nutritional Information

Per serving Calories 670 Total Fat 32 g Carbohydrates 57 g Protein 41 g

Delicious fettuccine, coated in a spicy Velveeta sauce, topped with succulent Cajun Chicken – a home-cooked meal! Pin it
Delicious fettuccine, coated in a spicy Velveeta sauce, topped with succulent Cajun Chicken – a home-cooked meal! | weeknightwhisk.com

This Cajun Chicken Alfredo is sure to impress and satisfy any craving for rich comforting flavors

Common Questions

How do I achieve a creamy Velveeta sauce?

Sauté butter and garlic, then stir in heavy cream and melted Velveeta cubes until smooth. Adding Parmesan enhances richness and texture.

What’s the best way to cook the Cajun-seasoned chicken?

Pat chicken dry, rub with Cajun seasoning, and sear in olive oil over medium-high heat until golden and cooked through, about 5–6 minutes per side.

Can I adjust the heat level in this dish?

Yes, modify the Cajun seasoning amount or omit the cayenne pepper for milder flavor, or add more cayenne for extra spice.

How do I keep the pasta from drying out?

Reserve some pasta water when draining and add small amounts to the sauce if it becomes too thick, ensuring a smooth, velvety coating.

What are good side dishes to complement this meal?

A crisp green salad and a chilled glass of Chardonnay pair well to balance the creamy, spicy pasta.

Can I substitute the chicken for a quicker option?

Yes, rotisserie chicken can be used as a convenient alternative without compromising flavor.

Cajun Chicken Alfredo Fettuccine

Tender Cajun chicken and creamy Velveeta sauce coat fettuccine for a rich, flavorful dish.

Prep Time
15 min
Cook Time
25 min
Time Needed
40 min
Created by Ella Thompson


Skill Level Easy

Cuisine American (Cajun-inspired)

Makes 4 Portions

Dietary Info None specified

What You'll Need

Chicken

01 2 large boneless, skinless chicken breasts
02 1 1/2 tablespoons Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 oz fettuccine pasta

Sauce

01 2 tablespoons unsalted butter
02 2 cloves garlic, minced
03 1 cup heavy cream
04 8 oz Velveeta cheese, cubed
05 1/2 cup grated Parmesan cheese
06 1/2 teaspoon black pepper
07 1/4 teaspoon cayenne pepper (optional)
08 Salt, to taste

Garnish

01 2 tablespoons fresh parsley, chopped
02 Extra grated Parmesan cheese (optional)

Step-by-Step

Step 01

Cook fettuccine: Bring a large pot of salted water to a boil. Cook fettuccine according to package directions until al dente. Drain, reserving 1/2 cup pasta water, and set aside.

Step 02

Prepare chicken: Pat chicken breasts dry and rub evenly with Cajun seasoning on both sides.

Step 03

Cook chicken: Heat olive oil in a large skillet over medium-high heat. Sear chicken 5 to 6 minutes per side until golden and cooked through (internal temperature 165°F). Remove from skillet, let rest 5 minutes, then slice thinly.

Step 04

Sauté garlic: Reduce skillet heat to medium. Add butter and minced garlic; sauté 1 minute until fragrant.

Step 05

Prepare sauce: Pour in heavy cream and bring to a gentle simmer. Add Velveeta cubes gradually, stirring constantly until melted and smooth.

Step 06

Season sauce: Stir in grated Parmesan, black pepper, and cayenne pepper if using. Adjust thickness by adding reserved pasta water incrementally until desired consistency is reached.

Step 07

Combine pasta and sauce: Toss cooked fettuccine in sauce until fully coated.

Step 08

Assemble and serve: Portion pasta onto plates, top with sliced Cajun chicken. Garnish with chopped parsley and additional Parmesan as desired.

Tools Required

  • Large pot
  • Large skillet
  • Knife and cutting board
  • Tongs or pasta fork
  • Measuring cups and spoons

Allergy Notice

Go through every ingredient to identify allergens and talk to your healthcare provider if you have concerns.
  • Contains dairy (Velveeta, Parmesan, cream, butter)
  • Contains wheat (fettuccine)
  • Contains poultry (chicken)

Nutrition Information (per portion)

Nutrition details are for general reference and shouldn't replace advice from your doctor.
  • Caloric Content: 670
  • Fats: 32 g
  • Carbohydrates: 57 g
  • Proteins: 41 g